Evaluation of Immune Parameters in Determining Mortality and Morbidity in Acute Biliary Pancreatitis


Thesis Type: Doctorate

Institution Of The Thesis: Istanbul University, Aziz Sancar Institute Of Experimental Medicine, Department Of Immunology, Turkey

Thesis Language: Turkish

Student: Ufuk Oğuz İdiz

Consultant: Ali Osman Gürol

Abstract:

In patients diagnosed with acute biliary pancreatitis, determining the course of the disease at the time of diagnosis is extremely important for treatment and survival. There are currently many biochemical analysis and imaging methods in the diagnosis of pancreatitis, and scoring systems are used to determine the clinical course in which they are jointly evaluated. In our study, it is aimed to evaluate the lymphocyte subgroups and blood cytokine and acute phase reactants levels by Flow cytometry and ELISA from blood at the time of diagnosis and to evaluate the correlation between mortality and morbidity ELISA in a wide series of patients. Our study will be carried out with an examination of the blood of patients who applied to Istanbul Training and Research Hospital for acute biliary pancreatitis. This study is planned to take place between 01.09.2019-01.07.2020. Acute biliary pancreatitis patients who applied to Istanbul Training and Research Hospital will be divided into groups by determining the severity of pancreatitis according to APACHE classification. There will be a control group who dont have any known diseases. Flow cytometry and ELISA analysis will be carried out for the determination of lymphocyte subtypes and cytokines at the Istanbul Training and Research Hospital by the researcher (Assoc. Prof. Ufuk Oğuz İdiz). Flow cytometry and ELISA results will be compared across all groups. No medication or medical treatment will be applied to the participants in this study. With the results obtained at the end of the study, it is aimed to reduce the patient morbidity and mortality and to reduce the hospital costs by early treatment of acute biliary pancreatitis patients.