Investigation of BDNF and Dopamine D2 Receptor Gene Variations Related to Weight Gain

Thesis Type: Postgraduate

Institution Of The Thesis: Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Molecular Medicine, Turkey

Thesis Language: Turkish

Student: Fatima Hilal Bektaş

Supervisor: Ali Osman Gürol



Neurotrophins are involved in neuronal plasticity processes and take part in the survival, differentiation, and maintenance of certain neuronal populations. Neurotrophins also play a role as selective retrograde messengers that regulate synaptic activity. Binding of this protein to its receptor increases neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, (5) Parkinson (3), and Huntington's disease (2) patients. This gene may play a role in regulating the stress response and in the biology of mood disorders (4).
Dopamine receptors are divided into two as D1-like and D2-like. D3 and D4, which are determined as dopamine receptor subtypes according to their functions, are called D2-like receptors, while D5 is classified as D1-like receptors. An important intracellular effect of D1-like receptors is that they activate adenylate cyclase via G-proteins, resulting in increased cAMP within the cell. (9) Cyclic AMP dependent protein kinase stimulates the phosphorylation of cellular proteins such as dopamine, cAMP-regulated phosphoprotein (DARPP-32) and phosphoprotein (ARPP-21, -16) (11). There is also evidence that various D1 receptor subtypes regulate the activities of ionic Ca +, K + and Na + channels (8).
D2 receptor stimulation has been observed to reduce adenylate cyclase activity. D2 receptors interact with a group of G proteins, resulting in a variety of secondary messenger effects, such as regulation of Ca2 + and K + channel functions and alteration in phosphoinositide production. (one)
The DRD2 gene is to encode the D2 subtype from dopamine receptors. While a mutation in this gene causes myoclonus dystonia (6), other mutations have been found to be related to schizophrenia. (7)

In our thesis, we will examine the variations of BDNF and DRD2 genes that may be associated with weight gain in the DNA of individuals with a body mass index of 30 kg / m2. In this way, we think that we can discuss whether obesity and brain functions, learning activities, and mood disorders can be related. Since this relationship has not been studied before, our thesis study will contribute to the literature.