Tüberküloz tedavisinde yeni bir seçenek olan rifabutinin M tuberculosis suşlarına karşı in vitro etkinliği

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Uzun M. (Yürütücü)

Yükseköğretim Kurumları Destekli Proje, 2000 - 2000

• Proje Türü: Yükseköğretim Kurumları Destekli Proje
• Başlama Tarihi: Ocak 2000
• Bitiş Tarihi: Aralık 2000

Proje Özeti

In order to indicate the cross-resistance between rifampin

(RMP) and rifabutin (RBU), minimal inhibitory concentrations

(MICs) of RBU were investigated in 50 Mycobacterium

tuberculosis strains. The MIC values of 25

RMP-susceptible (to 2 g/ml) and 25 RMP-resistant (to

2 g/ml) M. tuberculosis strains against RBU were

determined by the Bactec TB 460 system. All of the

RMP-susceptible strains were also susceptible to RBU

(MIC 1 g/ml). Three out of 25 (12%) RMP-resistant

strains were determined as susceptible to RBU. The high

level cross-resistance (88%) obtained in this study highlights

the importance of testing susceptibility to RBU

prior to its inclusion in the tuberculosis treatment regimens

at the Istanbul Faculty of Medicine.

KEY WORDS: rifampin; rifabutin; cross-resistance; M.

tuberculosis