Impact of UCP2 -866G/A Variant on Smoking Risk

NURSAL A. F., Uysal M. A., PEHLİVAN M., Sever U., Pehlivan S.

BEZMIALEM SCIENCE, cilt.9, sa.2, ss.185-189, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.14235/bas.galenos.2020.4159
  • Dergi Adı: BEZMIALEM SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.185-189
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been reported to affect mitochondrial function both in vitro and in vivo. Uncoupling protein 2 (UCP2) reduces generation of ROS by mitochondria. Our purpose in this study was to investigate whether the -866G/A variant of the UCP2 gene is associated with smoking status.