Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer

Demokan S., SÜOĞLU Y. H., Demir D., Gözeler M., Dalay N.

ANNALS OF ONCOLOGY, cilt.17, sa.6, ss.995-999, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1093/annonc/mdl048
  • Dergi Adı: ANNALS OF ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.995-999
  • Anahtar Kelimeler: methylation, hMLH1, hMSH2, microsatellite instability, head and neck cancer, SQUAMOUS-CELL CARCINOMA, PROMOTER HYPERMETHYLATION, HMLH1 PROMOTER, PROTEIN EXPRESSION, HMSH2, INACTIVATION, PHENOTYPE, FREQUENCY, TUMORS, MLH1
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Methylation in the promoter region of the DNA mismatch repair genes hMLH1 and hMSH2 and microsatellite instability at three loci were analyzed in the tumor tissue from patients with head and neck cancer.