Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children


SCHAEFER F., Trachtman H., WUHL E., KIRCHNER M., Hayek S. S. , Anarat A., ...More

JAMA PEDIATRICS, vol.171, no.11, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 171 Issue: 11
  • Publication Date: 2017
  • Doi Number: 10.1001/jamapediatrics.2017.2914
  • Journal Name: JAMA PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded, Scopus

Abstract

IMPORTANCE Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level and cystatin C-derived estimated glomerular filtration rate (eGFR) and assessment of proteinuria in spot or timed urine samples, are of limited value in identifying patients at risk of progressive kidney function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 in adults.