Vagus nerve stimulation inhibits seizure activity and protects blood-brain barrier integrity in kindled rats with cortical dysplasia


Kaya M. , Orhan N. , Karabacak E., Bahceci M. B. , Arican N. , Ahishali B. , ...More

LIFE SCIENCES, vol.92, pp.289-297, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92
  • Publication Date: 2013
  • Doi Number: 10.1016/j.lfs.2013.01.009
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.289-297
  • Keywords: Cortical dysplasia, Vagus nerve stimulation, Blood-brain barrier, TUBEROUS SCLEROSIS, P-GLYCOPROTEIN, REFRACTORY EPILEPSY, ANIMAL-MODELS, MALFORMATIONS, EPILEPTOGENESIS, EXPRESSION, PHARMACORESISTANCE, NOREPINEPHRINE, HIPPOCAMPUS

Abstract

Aims: This study investigates the effects of vagus nerve stimulation (VNS) on seizure severity and blood-brain barrier (BBB) integrity in kindled rats with cortical dysplasia (CD).