Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity

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Demir M. G., Altıntoprak N., Aydin S., Kosemihal E., Basak K.

JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY, vol.11, no.3, pp.202-206, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 11 Issue: 3
• Publication Date: 2015
• Doi Number: 10.5152/iao.2015.1084
• Journal Name: JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.202-206
• Istanbul University Affiliated: No

Abstract

OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity.