Aquaporin-1 Antibody in Neuromyelitis Optica Patients

Tuzun E., TZARTOS J., Ekizoglu E., STERGIOU C., ZISIMOPOULOU P., Coban A., ...More

EUROPEAN NEUROLOGY, vol.72, pp.271-272, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72
  • Publication Date: 2014
  • Doi Number: 10.1159/000364904
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.271-272
  • Keywords: Aquaporin-1, Aquaporin-4, Neuromyelitis optica, Antibody, Autoimmunity
  • Istanbul University Affiliated: Yes


Background/Methods: To find out the prevalence of aquaporin-antibody (Aqp-Ab) and characterize Aqp-Ab associated clinical features in NMO, Aqp-1 and Aqp-4-Abs were examined using radioimmunoprecipitation and cell-based assays, respectively. Results: Aqp-4 and Aqp-1-Abs were detected in 20/30 and 8/30 NMO patients, respectively. One patient was Aqp-1-Ab single-positive, 13 patients were Aqp-4-Ab single-positive, 7 patients were Aqp-4/Aqp-1-Ab double-positive and 9 patients were seronegative. All double-positive patients had optic neuritis during the first attack. Only 2/29 MS patients and none of the control idiopathic intracranial hypertension patients were Aqp-1-Ab positive. Conclusion: Aqp-1-Ab is usually detected in Aqp-4-Ab positive NMO patients and might be involved in optic neuritis pathogenesis. (C) 2014 S. Karger AG, Basel