Aquaporin-1 Antibody in Neuromyelitis Optica Patients

Tuzun E., TZARTOS J., Ekizoglu E., STERGIOU C., ZISIMOPOULOU P., Coban A., ...Daha Fazla

EUROPEAN NEUROLOGY, sa.5-6, ss.271-272, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1159/000364904
  • Dergi Adı: EUROPEAN NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.271-272
  • Anahtar Kelimeler: Aquaporin-1, Aquaporin-4, Neuromyelitis optica, Antibody, Autoimmunity
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/Methods: To find out the prevalence of aquaporin-antibody (Aqp-Ab) and characterize Aqp-Ab associated clinical features in NMO, Aqp-1 and Aqp-4-Abs were examined using radioimmunoprecipitation and cell-based assays, respectively. Results: Aqp-4 and Aqp-1-Abs were detected in 20/30 and 8/30 NMO patients, respectively. One patient was Aqp-1-Ab single-positive, 13 patients were Aqp-4-Ab single-positive, 7 patients were Aqp-4/Aqp-1-Ab double-positive and 9 patients were seronegative. All double-positive patients had optic neuritis during the first attack. Only 2/29 MS patients and none of the control idiopathic intracranial hypertension patients were Aqp-1-Ab positive. Conclusion: Aqp-1-Ab is usually detected in Aqp-4-Ab positive NMO patients and might be involved in optic neuritis pathogenesis. (C) 2014 S. Karger AG, Basel