Resting-State Functional Connectivity Alterations in Drug-Naive Adolescents with Obsessive-Compulsive Disorder


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Kinay D., Yildiz Ç., Kurt E., Eryurek K., Demiralp T., Coşkun M.

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.31, no.1, pp.40-47, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.5152/pcp.2021.20169
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.40-47
  • Keywords: Default mode network (DMN), functional connectivity, Independent component analysis (ICA), pediatric, resting-state networks (RSN)
  • Istanbul University Affiliated: Yes

Abstract

Objective: It is known that there are alterations in functional brain networks in pediatric obsessive-compulsive disorder (OCD) and new studies are needed to identify and conceptualize these alterations. This study aimed to investigate resting-state functional connectivity (Rs-FC) changes in adolescents with OCD. Materials and Methods: We compared FC alterations in 15 drug-naive adolescents with OCD and 15 healthy controls (HC). Rs-FC networks were obtained with independent component analysis and logistic regression was used to identify the components that displayed significant group differentiation. Results: Data were decomposed into 30 independent components, and 4 components corresponding to functional networks showed a significant difference between the 2 groups (sensitivity and specificity value was 86.7%): Posterior cingulate cortex (PCC), cerebellum, right frontoparietal network (R-FPN), and anterior DMN (aDMN). The expression scores of the PCC, cerebellum, and R-FPN were significantly lower in OCD, while the expression score of the aDMN was significantly higher in OCD as compared with HC. In addition, OCD patients demonstrated a significant anti-correlation between the R-FPN and lateral sensorimotor network, and a positive correlation between the PCC and parahippocampal gyri. Conclusion: These findings indicate that alterations in FC networks incumbent on high mental processes are involved in the pathophysiology of OCD in adolescents.