Prevalence of occult hepatitis B infection in liver biopsy sample of patients with nonviral liver disease

Çakal B., Atasoy A., Çavuş B., Poda M., Bulakçı M., Güllüoğlu M., ...Daha Fazla

FUTURE VIROLOGY, cilt.17, sa.10, ss.733-742, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2022
  • Doi Numarası: 10.2217/fvl-2021-0316
  • Dergi Adı: FUTURE VIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.733-742
  • Anahtar Kelimeler: hepatitis B, histopathology, liver biopsy, nonviral liver disease, occult HBV infection, prevalence, total hepatitis B core antibody, VIRUS-INFECTION, HBV INFECTION, HEPATOCELLULAR-CARCINOMA, SURFACE-ANTIGEN, REACTIVATION, PERSISTENCE, DNA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: To determine the prevalence of occult hepatitis B (HBV) infection (OBI) in patients with nonviral liver disease. Materials & methods: This study included 83 HBsAg-negative patients followed up at a gastroenterohepatology clinic. The presence of HBV DNA was investigated by using an in-house nested-PCR method applied to liver parenchymal biopsy samples obtained from patients who underwent due nonviral chronic liver disease. Results: OBI was detected in 19 (22.9%) of the 83 cases, in 11 (44%) of 25 anti-HBc-positive patients, and 15 (31.9%) of 47 anti-HBc and/or anti-HBs antibodies-positive patients. Conclusion: There is a considerable prevalence of OBI among patients with nonviral chronic liver disease. Therefore, it is suggested that closely monitoring HBV can be useful to prevent or more effectively manage possible OBI-related complications among patients with nonviral chronic liver disease, especially those who are HBsAg seronegative or anti-HBV antibody seropositive.