Diagnosis and management of pediatric adrenal insufficiency

Ucar A., Bas F., Saka N.

WORLD JOURNAL OF PEDIATRICS, cilt.12, sa.3, ss.261-274, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s12519-016-0018-x
  • Dergi Adı: WORLD JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.261-274
  • Anahtar Kelimeler: adrenal insufficiency, critical illness, hypothalamo-pituitary-adrenal axis, iatrogenic, steroids, STEROID WITHDRAWAL SYNDROME, FAMILIAL GLUCOCORTICOID DEFICIENCY, MODIFIED-RELEASE HYDROCORTISONE, SERUM-FREE CORTISOL, ADDISONS-DISEASE, CORTICOSTEROID INSUFFICIENCY, ANTIPHOSPHOLIPID SYNDROME, CORTICOTROPIN TEST, AXIS SUPPRESSION, CRITICAL ILLNESS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Adrenal insufficiency (AI) is a wellknown cause of potentially life-threatening disorders. Defects at each level of the hypothalamic-pituitary-adrenal axis can impair adrenal function, leading to varying degrees of glucocorticoid (GC) deficiency. Iatrogenic AI induced by exogenous GCs is the most common cause of AI. The criteria for the diagnosis and management of iatrogenic AI, neonatal AI, and critical illness-related corticosteroid insufficiency (CIRCI) are not clear.