Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model

Imamoglu S., Imamoglu E. Y., Erdenoz S., CUMBUL A., Uslu F., AktaS S., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.4, ss.2198-2205, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2012-119
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.2198-2205
  • Anahtar Kelimeler: Hypoxia-ischemia, magnesium sulfate, neuroprotection, retina, ENDOTHELIAL GROWTH-FACTOR, BRAIN-INJURY, EXPRESSION, RECEPTOR, ACTIVATION, EXPOSURE, NEURONS, PROTECT
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/aim: The effects of systemic magnesium sulfate (MgSO4) on retina in pretenn hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2), and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model.