COMPUTERISED DESIGNING OF DOXORUBICIN WITH BREAST CANCER CELLS


Sener L., Gunduz S., Şener A., Bicak B., Kokcu Y., Ozel A., ...More

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.82, no.1, pp.40-46, 2019 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.26650/iuitfd.0005
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.40-46

Abstract

Objective: Breast cancer is the type of cancer that starts in breast cells and has the highest incidence in the world after lung cancer. Doxorubicin is widely used in the treatment of some leukemia and Hodgkin's lymphoma, as well as in the treatment of bladder, breast, stomach, lung, ovary, thyroid, soft tissue sarcoma, multiple myeloma and other cancers. We want to determine the binding interaction of Doxorubicin in the active site of the Galectin-3 with ASN-48, ARG-32, ASN-62 and GLU-72 residues, conformation and docking score energies.