In Vitro Inhibitory Effect of Succinic Acid on T-Cell Acute Lymphoblastic Leukemia Cell Lines

Ertuğrul B., Iplik E. S., Çakmakoğlu B.

ARCHIVES OF MEDICAL RESEARCH, cilt.52, sa.3, ss.270-276, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.arcmed.2020.10.022
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.270-276
  • Anahtar Kelimeler: Succinic acid, T-cell acute lymphoblastic leukemia, Apoptosis, ALPHA-TOCOPHERYL SUCCINATE, VITAMIN-E SUCCINATE, PROSTATE-CANCER, APOPTOSIS, CARCINOMA, AGENT
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and aims. Although several treatment regimens for T-cell acute lympho-blastic leukemia (T-ALL), trouble is still ongoing that relapse of disease after therapies in both pediatric and adult patients. Hence, the demand for new alternative therapeutics that are antiproliferative for cancer cells but do not harm healthy cells in treatments is increasing day by day. This study aimed to investigate whether succinic acid show anti-proliferative and apoptotic effect of on T-ALL cell lines.