Synthesis and Biological Activity of New 1,3-Dioxolanes as Potential Antibacterial and Antifungal Compounds


Kucuk H. B., Yusufoglu A. S., Mataraci E., Dosler S.

MOLECULES, cilt.16, sa.8, ss.6806-6815, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3390/molecules16086806
  • Dergi Adı: MOLECULES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6806-6815
  • Anahtar Kelimeler: 1,3-dioxolanes, montmorillonite K10, diols, antibacterial activity, antifungal activity, ASYMMETRIC-SYNTHESIS, CARBONYL-COMPOUNDS, DERIVATIVES, INHIBITORS, ACETALS, KETALS
  • İstanbul Üniversitesi Adresli: Evet

Özet

A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa.