Clinical management of a challenging malignancy, osteoblastoma-like osteosarcoma: a report of four cases and a review of the literature

OZGER H., Alpan B. , SOYLEMEZ M. S. , ÖZKAN K., Salduz A. , Bilgic B., ...More

THERAPEUTICS AND CLINICAL RISK MANAGEMENT, vol.12, pp.1261-1270, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 12
  • Publication Date: 2016
  • Doi Number: 10.2147/tcrm.s102966
  • Page Numbers: pp.1261-1270
  • Keywords: osteoblastoma-like osteosarcoma, differential diagnosis, biopsy


Osteoblastoma-like osteosarcoma, a rare form of osteosarcoma, is a malignant lesion associated with risks of both local recurrence and distant metastasis. The differential diagnosis of osteoblastoma-like osteosarcoma from osteoblastoma and aggressive osteoblastoma remains controversial and challenging. Previous studies suggest that these three types of tumor are distinct entities. However, working out a precise diagnosis may not always be possible immediately on the basis of initial clinical, radiological, and histopathological features. On the other hand, the importance of a correct diagnosis cannot be overemphasized since the treatment strategies change dramatically according to the nature of the lesion. In all of our cases, initial Tru-Cut biopsies revealed osteoblastic features with minimal atypia, but further biopsies confirmed malignancy. A high index of suspicion and considerable experience are prerequisites for accurate diagnosis in case of clinicopathological and radiological discordance.