Akademik Veri Yönetim Sistemi
American Society for Blood and Marrow Transplantation Best of ASBMT Tandem Meetings, İstanbul, Türkiye, 27 - 28 Mart 2015
Object:
Peripheral blood and bone marrow stem
cells are frequently used for treatment
of hematopoietic malignancies. The use of cord blood units has been increasing
for hematopoietic stem cell transplantations (HSCTs). Human leukocyte antigens
(HLA) matching is crucial for succesful transplant
outcome.
Provision of unrelated stem cells is
more difficult for patients within
minority groups. Besides HLA matching,availability of the donor for the
procedure may also cause delays. HLA matching requirement between donor and
patient is less crucial for cord blood transplantation presumably due to
tolerance development during pregnancy.
The number of unrelated HSCTs performed
in Turkey has been increasing. The use of cord blood units has also increased
significantly in the recent years. In this study, the main goal was to
determine the effect of HLA matching on survival after cord blood
transplantation.
Material
and Method: Between
2008 and 2014, cord blood unit search applications for 102 patients resulted in
a transplantation through İstanbul University, Istanbul Medical Faculty, Bone
Marrow Bank.
Findings: It was on
average 45 days between the search request and transplantation ( range:11-113
days).
Average age of the patients is 4,3 ±
2,8 (1-30 years), male-to-female ratio was 64/38. The most frequent diseases
resulting in transplantation were SCID (n=23), AML (n=13), osteopetrosis (n=10)
and ALL (n=10).
There were 39 (38 %) cord blood transplantations with matched HLA
-A, -B, -DR; 54 (52%) mismatched for HLA-A or -B antigens; 9 (9%) mismatched
for HLA-DR only and 1 (1%) mismatched for HLA-B and -DR antigens.
The overall survival rate after HSCT with cord blood was
79.4% (n= 31/39).
The overall survival rate of the patients with Class-I antigens
mismatch is 51.8% (26/54), the patients
with Class-II antigens mismatch is 77,7%
(2/9) after the HSCT.