Guliyeva L., Trawally M., Demir-Yazıcı K., Kaya K., Akdemir A., Güzel-Akdemir Ö.
8th International Students Science Congress, İzmir, Türkiye, 23 - 24 Mayıs 2024, ss.141, (Özet Bildiri)
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Yayın Türü:
Bildiri / Özet Bildiri
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Doi Numarası:
10.52460/issc.2024.060
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Basıldığı Şehir:
İzmir
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Basıldığı Ülke:
Türkiye
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Sayfa Sayıları:
ss.141
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İstanbul Üniversitesi Adresli:
Evet
Özet
Thiosemicarbazones are Schiff bases formed by condensing an aldehyde or ketone with thiosemicarbazide derivatives. TSCs exhibit various biological activities and act as precursors for key scaffolds, with keto-enol tautomerism commonly resulting in thione or thiol forms. This study focuses on synthesizing and confirming the structure of compound 1, (E)-2-(1-(4-cyanophenyl)ethylidene)-N-(2-fluoro-4-sulfamoylphenyl)hydrazine-1-carbothioamide, through a condensation reaction in methanol. Both theoretical and experimental IR and X-ray studies confirm the presence of the thione form and E isomerism. Compound 1 showed inhibitory activity against four human carbonic anhydrase isoforms (hCA I, II, IX, XII) with Ki values of 36.0, 5.7, 29.5, and 7.0 nM, respectively.