Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies

TOPÇU G., AKDEMİR A., KOLAK U., Ozturk M., Boga M., BAHADORİ F., ...Daha Fazla

CURRENT ALZHEIMER RESEARCH, cilt.17, sa.3, ss.269-284, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1567205017666200424133534
  • Dergi Adı: CURRENT ALZHEIMER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo
  • Sayfa Sayıları: ss.269-284
  • Anahtar Kelimeler: Alzheimer's Disease, cholinesterase inhibition, acetylcholinesterase, butyrylcholinesterase, antioxidant, docking studies, abietane diterpenoids, Salvia, ALZHEIMERS-DISEASE, ANTIBACTERIAL DITERPENES, BIOACTIVE CONSTITUENTS, CYTOTOXIC ACTIVITY, SALVIA EXTRACTS, ROOTS, TERPENOIDS, BUTYRYLCHOLINESTERASE, INHIBITORS, THERAPY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Alzheimer's Disease (AD) is one of the most prevalent causes of dementia in the world, and no drugs available that can provide a complete cure. Cholinergic neurons of the cerebral cortex of AD patients are lost due to increased activity of cholinesterase enzymes.