In present study, the behavior of ytterbium (III) oxide, samarium (III) oxide and neodymium (III) oxide reinforced novel TeO2–B2O3–V2O5 (TBV groups, tellurite-vanadium–boro) glasses groups are investigated against heavy charged particles, on mass stopping power, projected range and KERMA parameters. SRIM and PAGEX codes are used for determination of the mass stopping power, projected range and KERMA parameters in a kinetic energy range of 0–10 MeV. The highest KERMA values of TBV(X) glasses were achieved at 0.6 MeV. Among TBV(X) glasses, the TBVY1.5 sample with the highest material density (i.e. 5.01038 g/cm3) had the highest KERMA value. The TBVY1.5 sample has the lowest projected range values for alpha and protons with the same kinetic energy. The lowest values of mass stopping power were reported for the TBVY and TBVS groups, which had the highest density values among the analyzed glass samples. The TBVY1.5 sample provides the greatest stopping and slowing characteristics for alpha and proton kinetic energies ranging from 0 to 10 MeV. In this case, it can be said that these two glass groups may slow down alpha particles with a certain kinetic energy the most effectively. It can be concluded that TBV(Y) and TBV(S) glass groups might be useful for stopping the alpha, proton and electron particles.