CD3(-)CD56(+) NK cells display an inflammatory profile in RR-MS patients

Tahrali I., Kucuksezer U. C., Akdeniz N., Altintas A., Uygunoglu U., Aktas-Cetin E., ...More

IMMUNOLOGY LETTERS, vol.216, pp.63-69, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 216
  • Publication Date: 2019
  • Doi Number: 10.1016/j.imlet.2019.10.006
  • Journal Name: IMMUNOLOGY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.63-69
  • Keywords: IL-22, Multiple sclerosis, Natural killer cells, NKG2A, NKG2D, NKp44, NATURAL-KILLER-CELLS, CD4(+) T-CELLS, MULTIPLE-SCLEROSIS, DISEASE-ACTIVITY, DENDRITIC CELLS, INNATE IMMUNITY, MIC LIGANDS, HLA-E, NKG2D, RECEPTOR
  • Istanbul University Affiliated: Yes

Abstract

Multiple Sclerosis (MS) is an immune-mediated and neurodegenerative disease of central nervous system. Relapsing-remitting (RR)-MS occurring with acute attacks and remissions, is the most common clinical type of MS. There are different strategies applied in first-line treatment of RR-MS patients such as interferon-beta (IFN-beta) and glatiramer acetate. In this study, activating and inhibitory receptor expressions and interleukin (IL)-22 levels of NK cells were investigated in RR-MS patients with or without IFN-beta therapy. Activating receptor expression and IL-22 levels of NK cells were increased in RR-MS patients under IFN-beta therapy. Elevated NK cells with activating profile and increased IL-22 under IFN-beta therapy suggest that IFN-beta treatment might direct NK cells toward a pro-inflammatory status.