Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-alpha and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease

GORMEZ S., DEMIRKAN A., Atalar F., Caynak B., ERDIM R., SÖZER V., ...Daha Fazla

INTERNAL MEDICINE, cilt.50, sa.8, ss.805-810, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2169/internalmedicine.50.4753
  • Dergi Adı: INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.805-810
  • Anahtar Kelimeler: metabolic syndrome, atherosclerosis, chemokines, inflammation, genes, IN-VIVO, ADIPOCYTOKINES, PROTEIN, WEIGHT, RISK
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective Metabolic syndrome (MS) is associated with an increased risk of coronary artery disease (CAD) and type 2 diabetes mellitus (DM). In MS, adipose tissue has been shown to function as a paracrine and an endocrine organ secreting various adipocytokines. In the current study, adiponectin, tumor necrosis factor-alpha (TNF-alpha) and leptin gene expressions in the epicardial adipose tissue (EAT), paracardial adipose tissue (PAT) and subcutaneous adipose tissue (SAT) were investigated in MS patients with CAD and in non-MS patients without CAD.