Increased costimulatory molecule expression of thymic and peripheral B cells and a sensitivity to IL-21 in myasthenia gravis

Hocaoglu, Mehmet; Durmus, Hacer; Ozkan, Berker; Yentur, Sibel; Dogan, Oner; Parman, Yesim; Deymeer, Feza; Saruhan-Direskeneli, Güher

doi:10.1016/j.jneuroim.2018.07.006

Increased costimulatory molecule expression of thymic and peripheral B cells and a sensitivity to IL-21 in myasthenia gravis

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Hocaoglu M., Durmus H., Ozkan B., Yentur S. P., Dogan O., Parman Y., ...More

JOURNAL OF NEUROIMMUNOLOGY, vol.323, pp.36-42, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 323
Publication Date: 2018
Doi Number: 10.1016/j.jneuroim.2018.07.006
Journal Name: JOURNAL OF NEUROIMMUNOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.36-42
Keywords: Myasthenia gravis, B cells, Thymus, IL-21, Co-stimulation, SELF-ANTIGENS, MEMORY, SCLEROSIS, THYMOMA
Istanbul University Affiliated: Yes

Abstract

B cells may contribute to the pathogenesis of myasthenia gravis with anti-acetylcholine antibodies (AChR + MG) by co-stimulation or selection of T cells.