Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection.

Medetalibeyoglu A., Bahat G., Senkal N., Kose M., Avcı K., Sayın G., ...More

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, vol.89, pp.104717, 2021 (SCI-Expanded) identifier identifier identifier


Background/objectives: COVID-19 followed a mortal course in some young patients without any underlying factors, however, it followed a very benign course in some very older individuals with multiple comorbidities. These observations question if some genetic factors may be related to the vulnerability and poor prognosis of the disease. In this study, we aimed to investigate whether MBL2 gene B variant at codon 54 (rs1800450) were related to the variabilities in clinical course of this infection.