Microrna analysis of human decidua mesenchymal stromal cells from preeclampsia patients

Kamali Simsek N., BENİAN A., Sevgin K., Ergun Y., Celik H. G., Karahuseyinoglu S., ...Daha Fazla

PLACENTA, cilt.115, ss.12-19, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 115
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.placenta.2021.09.004
  • Dergi Adı: PLACENTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.12-19
  • Anahtar Kelimeler: Preeclampsia, Human decidua mesenchymal stromal cell, MicroRNA, Droplet digital PCR, STEM-CELLS, CHORIONIC VILLI, EXPRESSION, PLACENTA, MIR-16, FETAL, ANGIOGENESIS, PREGNANCIES, DIFFERENTIATION, PROLIFERATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: In preeclampsia (PE), human decidua mesenchymal stromal cells (hDMSCs) are exposed to abnormally high levels of oxidative stress and inflammatory factors circulating in the maternal blood. MicroRNAs (miRNAs) have been shown to have a significant impact on the differentiation, maturation and function of mesenchymal stromal cells (MSCs). Our aim in the present study is firstly to investigate differentially expressed miRNA levels to be used as a biomarker in the early detection of PE and secondly to investigate whether those differentially expressed miRNAs in hDMSCs have an effect on the pathogenesis of PE.