Aplication of Platelet-rich plasma during oral surgery in a patient with Werner syndrome

Kocaelli H., Apaydın A., Ayhan M., Güven E., Aktaş Ş., Balcıoğlu N.

22nd International Conference on Oral and Maxillofacial Surgery, Melbourne, Australia, 27 - 30 October 2015, vol.44, pp.248

  • Publication Type: Conference Paper / Summary Text
  • Volume: 44
  • Doi Number: 10.1016/j.ijom.2015.08.195
  • City: Melbourne
  • Country: Australia
  • Page Numbers: pp.248


Background: Werner syndrome (WS) is a rare autosomal

recessive premature aging disease that affects connective tissue. It

causes atherosclerosis, arteriosclerosis, eye abnormalities, osteoporosis,

soft tissue calcification, premature thinning, graying, and

loss of hair, some types of cancers, as well as impaired tissue


Objectives: We report a 46-year-old male patient with WS

who had undergone a minor oral surgical procedure followed by

application of platelet-rich plasma (PRP) and hyperbaric oxygen

therapy (HBOT). Seven years of follow-up was uneventful.

Findings and conclusions:Aprominent feature ofWSis atrophy

and wasting of the soft tissue and muscles. Because wound

healing is delayed in WS, even in minor surgical operations some

precautions such as PRP application and HBOT are possible

options. Death, on average, is at almost 47 years, and the primary

cause is arteriosclerosis, diabetes mellitus, or cancer.

Surgeons must pay particular attention to use careful incision

and flap raising techniques, which are essential to facilitate

tension-free closure and avoid skin and mucosal necrosis.

Surgical treatment may be unpredictable, and strict follow-up is