Malignant Transformation of Parotid Gland Non-sebaceous Lymphadenoma: Case Report and Review of Literature


Kara H., Sonmez S., Bagbudar S., Gulluoglu M., Basaran B.

Head and Neck Pathology, cilt.14, sa.4, ss.1123-1128, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s12105-020-01133-3
  • Dergi Adı: Head and Neck Pathology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1123-1128
  • Anahtar Kelimeler: Non-sebaceous, Lymphadenoma, Parotid, Malignant transformation, SALIVARY-GLAND, NONSEBACEOUS LYMPHADENOMA, DIFFERENTIATION, TUMOR
  • İstanbul Üniversitesi Adresli: Evet

Özet

Non-sebaceous lymphadenoma is a sporadic benign tumor of salivary glands. Histopathologic and immunohistochemical properties, diagnostic criteria, and theories for the histologic origin of the disease have been defined and well-discussed in the literature. However, none of the cases showed malignant transformation to date. We reported a case of 54 years old female patient with a right preauricular mass. Magnetic resonance imaging demonstrated a 2 cm, well-defined contrast-enhanced mass in the right parotid gland. Fine needle aspiration cytology was undiagnostic but suspicious for malignancy. Total parotidectomy with facial nerve preservation was done. In the histopathological examination, non-sebaceous lymphadenoma regions and malignant cells with abundant cytoplasm, large vesicular nuclei, and prominent nucleoli, which occupied approximately 70% of the mass, were seen. The diagnosis was undifferentiated carcinoma arisen from non-sebaceous lymphadenoma. Adjuvant radiotherapy was given. No recurrence was detected during ten months of follow-up. This case is the first case of a malignancy developed from non-sebaceous lymphadenoma.