Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring


FASEB JOURNAL, vol.21, no.4, pp.1264-1270, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1096/fj.06-7223com
  • Journal Name: FASEB JOURNAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1264-1270
  • Keywords: sensitization against food, sucralfate, digestion, children, lactation, BREAST-MILK, HYPERSENSITIVITY, IMMUNIZATION, SUCRALFATE, CHEMOKINES, EXPOSURE, PROTEIN, CELLS, MICE
  • Istanbul University Affiliated: No


The treatment of dyspeptic disorders with anti-acids leads to an increased risk of sensitization against food allergens. As these drugs are taken by 30-50% of pregnant women due to reflux and heartburn, we aimed here to investigate the impact of maternal therapy with anti-acids on the immune response in the offspring in a murine model. Codfish extract as model allergen was fed with or without sucralfate, an anti-acid drug, to pregnant BALB/c mice during pregnancy and lactation. These mothers developed a codfish-specific allergic response shown as high IgG1 and IgE antibody levels and positive skin tests. In the next step we analyzed whether this maternal sensitization impacts a subsequent sensitization in the offspring. Indeed, in stimulated splenocytes of these offspring we found a relative Th2-dominance, because the Th1- and T-regulatory cytokines were significantly suppressed. Our data provide evidence that the anti-acid drug sucralfate supports sensitization against food in pregnant mice and favors a Th2-milieu in their offspring. From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants.