Investigation of catechol-O-methyltransferase and cannabinoid receptor 2 gene variants in tobacco use disorder or tobacco use disorder and schizophrenia comorbidity Tütün kullanım bozukluğu veya tütün kullanım bozukluğu ve şizofreni komorbiditesinde katekol-o-metiltransferaz ve kannabinoid reseptör 2 gen varyantlarının incelenmesi

Creative Commons License

Pehlivan S., Çetinay Aydin P., Aytaç H. M., Uysal M. A., Sever Ü., Pehlivan M.

Anadolu Psikiyatri Dergisi, cilt.21, sa.6, ss.572-578, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5455/apd.91159
  • Dergi Adı: Anadolu Psikiyatri Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Psycinfo, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.572-578
  • Anahtar Kelimeler: COMT, CNR2, tobacco, schizophrenia, PCR-RFLP, COMT VAL(108/158) MET, SMOKING-CESSATION, FUNCTIONAL POLYMORPHISM, NICOTINE DEPENDENCE, CIGARETTE-SMOKING, DOPAMINE RELEASE, WORKING-MEMORY, ASSOCIATION, GENOTYPE, PERFORMANCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

© 2020, Cukurova University, Faculty of Medicine. All rights reserved.Objective: The purpose of this study was to investigate whether functional variants of Catechol-O-Methyltrans-ferase (COMT) (rs4680) and Cannabinoid Receptor 2 (CNR2) (rs2501432) genes play a role in tobacco use disorder (TUD) or tobacco use disorder and schizophrenia (TUDSch) comorbidity. Methods: This study consisted of 163 participants with TUD, 60 participants with TUDSch, and 106 gender-, age-and ethnicity-matched non-smoker controls (HNC). While the TUD and TUDSch were diagnosed according to the DSM-5, the severity of TUD was rated according to the Fagerstrom Test for Nicotine Dependence. Genotyping of COMT and CNR2 genes was determined using the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results: Distributions of genotypes and allele frequencies were compared among the groups. Patients with TUDSch had higher frequency of COMT Val/Val genotype compared to the TUD and HNC groups (p=0.001, p=0.034, respecttively). Patients with TUD had higher frequency of Val/Met genotype than TUDSch and HNC groups (p=0.001, p=0.033, respectively). The frequency of the Val allele was higher in TUDSch than the HNC group, whereas the frequency of the Met allele was higher in TUD than in the TUDSch group (p=0.047, p=0.001, respectively). Additionally, patients with TUD had higher frequency of TT CNR2 genotype than the HNC group (p=0.019). Conclusion: While the Val/Val genotype of the COMT gene is associated with an increased risk for TUDSch, the Val/Met genotype is associated with an increased risk for TUD. Additionally, the TT CNR2 genotype was associated with in creased risk for TUD in the Turkish population.