Isatin analogs as novel inhibitors of Candida spp. beta-carbonic anhydrase enzymes

Akdemir A., Guzel-Akdemir O., Karali N. L., Supuran C. T.

BIOORGANIC & MEDICINAL CHEMISTRY, cilt.24, sa.8, ss.1648-1652, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.bmc.2016.02.036
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1648-1652
  • Anahtar Kelimeler: Carbonic anhydrase, Carbonic anhydrase inhibitors, Candida, Isatins, Sulfonamides, CRYPTOCOCCUS-NEOFORMANS, CO2, IX, SULFONAMIDES, GLABRATA, PATENT, XII, VIRULENCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Enzyme inhibition data of structurally novel isatin-containing sulfonamides were determined for two carbonic anhydrases (CAs, EC 4.2.1.1) from pathogenic Candida species (CaNce103 from C. albicans and CgNce103 from C. glabrata). The compounds show K-I values in the low nanomolar range for the fungal CAs, while they have significantly higher K-I values for the human CAs. Homology models were constructed for the CaNce103 and CgNce103 and subsequently the ligands were docked into these models to rationalize their enzyme inhibitory properties. (C) 2016 Elsevier Ltd. All rights reserved.