Q192R and L55M Polymorphisms of Paraoxonase 1 Gene in Chronic Myelogenous Leukemia and Chronic Lymphocytic Leukemia

TOMATIR A. G., Pehlivan S., ŞAHİN H. H., OĞUZKAN BALCI S., Budeyri S., PEHLİVAN M.

ANTICANCER RESEARCH, cilt.35, sa.9, ss.4807-4812, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 9
  • Basım Tarihi: 2015
  • Dergi Adı: ANTICANCER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.4807-4812
  • Anahtar Kelimeler: Paraoxonase-1 (PON1), Q192R polymorphism, L55M polymorphism, chronic myeoloid leukemia (CML), chronic lymphocytic leukemia (CLL), PCR-RFLP, SERUM PARAOXONASE, BREAST-CANCER, TURKISH POPULATION, PON1 POLYMORPHISMS, PROSTATE-CANCER, RISK, ASSOCIATION, DISEASE, SUSCEPTIBILITY, DNA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients. Materials and Methods: We analyzed samples from 60 patients with CML, 60 with CLL and 84 healthy controls. Polymerase Chain Reaction (PCR) - Restriction Fragment Length Polymorphism (RLFP) was performed and samples were run in agarose gel. Results: We found statistically significant results showing an increase in both the RR genotype (p=0.044) and the R allele (p=0.011) for PON1 Q192R, and an increase in the MM genotype (p=0.007) and a decrease in the LL genotype (p=0.004) and R allele (p=0.001) in PON1 L55M in patients with CLL. Conclusion: We concluded that both the Q192R gene polymorphism with an increase in the genotype R allele, and the M/L55 with an increase in the MM genotype play a role in CLL susceptibility, and a decrease in the LL genotype can act against disease in the Turkish population.