Imaging of Chemokine Receptor CXCR4 in Mycosis Fungoides Using 68Ga-Pentixafor PET/CT


Kuyumcu S., Yilmaz E., Buyukkaya F., Ozkan Z. G., Unal S. N.

CLINICAL NUCLEAR MEDICINE, cilt.43, sa.8, ss.606-608, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 43 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1097/rlu.0000000000002166
  • Dergi Adı: CLINICAL NUCLEAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.606-608
  • Anahtar Kelimeler: Ga-68-Pentixafor, Mycosis fungoides, FDG, CXCR4, EXPRESSION
  • İstanbul Üniversitesi Adresli: Evet

Özet

A 52-year-old woman diagnosed with mycosis fungoides was referred for F-18-FDG PET/CT before treatment for the evaluation of disease severity. The patient also underwent Ga-68-pentixafor PET/CT for further evaluation. FDG uptake was observed in cervical, axillary, and pelvic lymph nodes and multiple widespread skin lesions throughout the body, suggestive of extensive involvement of mycosis fungoides. All lesions were visually identifiable with high target-to-background ratio on Ga-68-pentixafor PET/CT which demonstrated marked CXCR4 expression in all lesions that were detected using F-18-FDG PET/CT.