Gamma oscillations predict treatment response to aripiprazole in bipolar disorder

Arikan M. K. , Gunver G. , Ilhan R., Oksuz O., Metin B.

JOURNAL OF AFFECTIVE DISORDERS, vol.294, pp.159-162, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 294
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jad.2021.07.044
  • Page Numbers: pp.159-162
  • Keywords: Aripiprazole, Bipolar disorder, Gamma oscillations, qEEG, Resistance


Objective: Treatment of Bipolar Disorder (BD) is a challenging issue. Aripiprazole monotherapy is a recommended option for the treatment of mania in BD. The electrophysiological markers of treatment response to aripiprazole could be potentially identified by quantitative Electroencephalography (qEEG). Methods: Twenty-four patients with BD were analysed retrospectively. Based on the percentage reduction in Young Mania Rating Scale, they were classified as responders (N = 14) and non-responders (N = 10) to aripiprazole monotherapy. Their resting-state qEEG recordings were examined. Spectral power across all frequency bands were calculated. Absolute powers for all frequency bands were compared between these groups. Results: Independent sample Mann-Whitney U test revealed that patients who did not respond to aripiprazole had greater gamma power than aripiprazole treatment responders. Conclusions: Based on the present findings, it can be proposed that excess in gamma power could be the electrophysiological biomarkers of unresponsiveness to aripiprazole treatment in BD.