Angiotensin Converting Enzyme Gene Polymorphisms In Male Infertility

PEHLİVAN S., Onay H., TAVMERGEN E., Goker N. T., ÇOĞULU M. Ö., ÖZKINAY F. F.

EUROPEAN JOURNAL OF THERAPEUTICS, cilt.14, sa.2, ss.15-17, 2008 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2008
  • Dergi Adı: EUROPEAN JOURNAL OF THERAPEUTICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.15-17
  • Anahtar Kelimeler: Infertility, ACE, Polymorphism, DNA, PCR
  • İstanbul Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the frequency of Angiotensin Converting Enzyme (ACE) polymorphism in patients with oLigospermia or azoospermia and to compare the frequency of polymorphism with the control group which included the men who hail a child within 5 years. ACE insersion (I) / deletion (D) polymorphism was investigated at 132 men; 71 of them were diagnosed as azoospermia, 31 of them were diagnosed were oligospermia and 30 of them were healthy control. Analysis revealed that azoospermic, oligospermic and controls in terms of polymorphisms, genotype and allele frequencies, the differences were not significant and were no deviations from the Hardy-Weinberg equilibrium. The DD polymorphism ratio was found to he low (27.5%, p<0.05) in the individuals diagnosed with oligospermia in comparison to normal and azoospermic males; however, this difference was not istatistically significant and it was attributed to sampling size could have provided significant relationship.