A case of primary immune deficiency presenting with nephrotic syndrome

Aydin Z., Gursu M., Ozturk S., KILIÇASLAN I., KAZANCIOĞLU R.

CLINICAL KIDNEY JOURNAL, vol.3, no.5, pp.456-458, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1093/ndtplus/sfq083
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.456-458
  • Keywords: amyloidosis, common variable immunodeficiency, nephrotic syndrome
  • Istanbul University Affiliated: Yes


Common variable immunodeficiency (CVID) is the most common form of severe antibody deficiency. The disorder is associated with a broad spectrum of clinical manifestations, including infections and chronic lung, gastrointestinal and autoimmune diseases. A 29-year-old female patient has had frequent sinopulmonary infections and gastroenteritis for the last 20 years and had been given broad-spectrum antibiotics for treatment. Immunoglobulin (Ig) levels were at undetectable levels. Renal biopsy was consistent with AA amyloidosis. She is now under follow-up with periodic intravenous Ig treatment without any infection during the last 10 months. CVID must be kept in mind in patients with recurrent sinopulmonary infections.