The effects of tibolone on the human primary glioblastoma multiforme cell culture and the rat C6 glioma model

Altinoz M. A., Albayrak S. B., Karasu A., Sabanci P. A., Imer M., Bilir A.

NEUROLOGICAL RESEARCH, cilt.31, sa.9, ss.923-927, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 9
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1179/174313209x383268
  • Dergi Adı: NEUROLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.923-927
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: In the light of recent advances in tumor biology and genetics, we hypothesized that tibolone, an estrogen receptor agonist, may have antiproliferative effects on primary human glioblastoma cells and rat C6 malignant glioma cell lines. We thought that tibolone should exert its antiproliferative effects by augmenting glial cell differentiation through the naive, nonhypermethylated estrogen receptors in the glioma cells.