Combination of <SUP>68</SUP>Ga-FAPI-04 and Dedicated Breast PET (MAMMI PET) Outperformed Breast MRI and <SUP>18</SUP>F-FDG PET/CT by Revealing Nipple and Skin Involvement of Breast Cancer

Has Simsek D., Oflas M., Yilmaz R., Tukenmez M., Kuyumcu S.

CLINICAL NUCLEAR MEDICINE, vol.49, no.6, 2024 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 49 Issue: 6
  • Publication Date: 2024
  • Doi Number: 10.1097/rlu.0000000000005088
  • Journal Name: CLINICAL NUCLEAR MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Keywords: 18F-FDG PET/CT, 68Ga-FAPI, breast cancer, dbPET, MAMMI PET
  • Istanbul University Affiliated: Yes

Abstract

A 41-year-old woman with newly diagnosed breast cancer had suspicious clinical findings of skin involvement on physical examination. The primary tumor had no FDG uptake in F-18-FDG PET/CT. Nipple and skin had no pathologic enhancement for invasion in breast MRI. Because the T stage was unclear, the patient underwent( 68)Ga-FAPI-04 PET/CT for further evaluation. Combination of Ga-68-FAPI-04 with dedicated breast PET (MAMMI PET) showed nipple and skin involvement of breast cancer with intense FAPI uptake. Consequently, a skin-sparing mastectomy was performed. Histopathological examination confirmed invasive lobular carcinoma infiltration of the deep dermis in the nipple and skin tissue.