Predictors of poor kidney outcome in children with C3 glomerulopathy

Pınarbaşı, As; Dursun, I; Gokce, I; Çomak, E; Saygılı, S; Bayram, Mt; Donmez, O; Melek, E; Tekcan, D; Çiçek, N; Yılmaz, D; Tabel, Y; Yıldırım, Zeynep; Bahat, E; Koyun, M; Soylu, A; Canpolat, N; Aksu, Bağdagül; Çelakıl, Me; Taşdemir, M; Benzer, M; Özçelik, G; Bakkaloğlu, Sa; Düşünsel, R

doi:10.1007/s00467-020-04799-7

Predictors of poor kidney outcome in children with C3 glomerulopathy

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Pınarbaşı A., Dursun I., Gokce I., Çomak E., Saygılı S., Bayram M., ...More

PEDIATRIC NEPHROLOGY, vol.36, no.5, pp.1195-1205, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 36 Issue: 5
Publication Date: 2021
Doi Number: 10.1007/s00467-020-04799-7
Journal Name: PEDIATRIC NEPHROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Page Numbers: pp.1195-1205
Keywords: Complement, CKD stage 5, Children, C3 glomerulopathy, Predictors, DENSE DEPOSIT DISEASE, MYCOPHENOLATE-MOFETIL, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, POSTINFECTIOUS GLOMERULONEPHRITIS, ECULIZUMAB, EXPERIENCE
Istanbul University Affiliated: Yes

Abstract

Background C3 glomerulopathy (C3G) is characterized by heterogeneous clinical presentation, outcome, and predominant C3 accumulation in glomeruli without significant IgG. There is scarce outcome data regarding childhood C3G. We describe clinical and pathological features, treatment and outcomes, and risk factors for progression to chronic kidney disease stage 5 (CKD5) in the largest pediatric series with biopsy-proven C3G.