Impact of Neuro-Behcet Disease Immunoglobulin G on Neuronal Apoptosis

Giris M., Bireller S., Kucukali C. I., Hanagasi H. A., Degirmencioglu S., Tuzun E.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.54, sa.1, ss.67-71, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/npa.2016.19421
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.67-71
  • Anahtar Kelimeler: Behcet disease, neuro-Behcet disease, immunoglobulin G, terminal deoxynucleotidyl transferase dUTP nick end labeling, neurotoxicity, NEUROLOGICAL INVOLVEMENT, ANTIBODIES, FEATURES, STRESS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Parenchymal neuro-Behcet disease (NBD) is encountered in 5%-15% of Behcet disease (BD) patients and is characterized by inflammation of the brainstem and diencephalon structures. Neuronal apoptosis has been shown to participate in neuronal cell loss. Anti-neuronal antibodies have been identified in NBD patients. However, the pathogenic properties of these antibodies have not been studied.