Cytogenetic Analysis and Examination of SOS1 Gene Mutation in a Turkish Family with Hereditary Gingival Fibromatosis

Pehlivan D., Abe S., Ozturk S., Kayhan K., Gunduz E., Cefle K., ...Daha Fazla

JOURNAL OF HARD TISSUE BIOLOGY, cilt.18, sa.3, ss.131-134, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.2485/jhtb.18.131
  • Dergi Adı: JOURNAL OF HARD TISSUE BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.131-134
  • Anahtar Kelimeler: Hereditary gingival fibromatosis, SOS1, Mutation, DRUG-INDUCED GINGIVAL, HEARING-LOSS, LOCUS, OVERGROWTH, MAPS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Hereditary Gingival Fibromatosis (HGF) is a rate, benign disorder characterized by slowly progressive fibrous overgrowth of the gingiva FIGF occurs in several forms as a Mendelian trait (usually as an autosomal dominant condition), in malformation syndromes, in chromosomal abnormality syndromes and side effect of several pharmacological agents Except Son of sevenless-1 (SOS1) gene mutation, molecular basis of HGF is unclear Here, we reported the cytogenetic and SOS1 gene mutation analysis in a Turkish family with 7 affected members through duce generations. whose features are consistent with the diagnosis of autosomal dominant. isolated hereditary gingival fibromatosis. To the best of our knowledge this is the lust large Turkish family with het editary gingival fibromatosis In this study, we excluded the chiomosomal abnormalities and the mutation in SOS1 gene at this family