PEDIATRIC NEPHROLOGY, vol.31, no.9, pp.1469-1476, 2016 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus
Urine heat shock proteins, Urinary tract infection, Children, Biomarker, HSP, CHRONIC KIDNEY-DISEASE, HEAT-SHOCK PROTEINS, FEBRILE INFANTS, HSP70, DIAGNOSIS
Heat shock proteins (HSPs) are a multi-family group of proteins which are upregulated by the cell in response to exposure to hazardous (stress) factors, including infectious agents, to prevent changes in protein structure. The aim of our study was to assess whether urine levels of the 70-kDa family of HSPs (HSP70s) increase in children with urinary tract infection (UTI) and to determine the optimal urine (u) HSP70 cut-off level to predict UTI in children.