Urine heat shock protein 70 levels as a marker of urinary tract infection in children

Yilmaz A., Yildirim Z. N., Emre S., Gedikbasi A., Yildirim T., Dirican A., ...Daha Fazla

PEDIATRIC NEPHROLOGY, cilt.31, sa.9, ss.1469-1476, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 9
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00467-016-3361-1
  • Dergi Adı: PEDIATRIC NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1469-1476
  • Anahtar Kelimeler: Urine heat shock proteins, Urinary tract infection, Children, Biomarker, HSP, CHRONIC KIDNEY-DISEASE, HEAT-SHOCK PROTEINS, FEBRILE INFANTS, HSP70, DIAGNOSIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Heat shock proteins (HSPs) are a multi-family group of proteins which are upregulated by the cell in response to exposure to hazardous (stress) factors, including infectious agents, to prevent changes in protein structure. The aim of our study was to assess whether urine levels of the 70-kDa family of HSPs (HSP70s) increase in children with urinary tract infection (UTI) and to determine the optimal urine (u) HSP70 cut-off level to predict UTI in children.