Urine heat shock protein 70 levels as a marker of urinary tract infection in children


Yilmaz A. , Yildirim Z. N. , Emre S. , Gedikbasi A. , Yildirim T., Dirican A. , ...More

PEDIATRIC NEPHROLOGY, vol.31, no.9, pp.1469-1476, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 9
  • Publication Date: 2016
  • Doi Number: 10.1007/s00467-016-3361-1
  • Journal Name: PEDIATRIC NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1469-1476
  • Keywords: Urine heat shock proteins, Urinary tract infection, Children, Biomarker, HSP, CHRONIC KIDNEY-DISEASE, HEAT-SHOCK PROTEINS, FEBRILE INFANTS, HSP70, DIAGNOSIS

Abstract

Heat shock proteins (HSPs) are a multi-family group of proteins which are upregulated by the cell in response to exposure to hazardous (stress) factors, including infectious agents, to prevent changes in protein structure. The aim of our study was to assess whether urine levels of the 70-kDa family of HSPs (HSP70s) increase in children with urinary tract infection (UTI) and to determine the optimal urine (u) HSP70 cut-off level to predict UTI in children.