Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy

Aydin S., Demir M. G., Oguztuzun S., Kilic M., Yılmaz C., Dirican O.

BIOMEDICAL PAPERS-OLOMOUC, cilt.163, sa.4, ss.349-354, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 163 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5507/bp.2019.002
  • Dergi Adı: BIOMEDICAL PAPERS-OLOMOUC
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.349-354
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives. The palatine tonsil is a significant part of the secondary immune system. Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this component. Although there are studies on their pathogenesis, there is insufficient study of the role of antioxidant agents. Glutathione S-transferase (GST) isozymes contribute to the antioxidation reactions in the tissue via the glutathione pathway. The purpose in this study was to reveal the levels of the GST enzyme activity and protein expression of GSTP1 and GSTA1 isozymes in patients with tonsillitis and tonsil hypertrophy, and to investigate their role in the pathogenesis of these diseases.