Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas


Pehlivan D., Gunduz E., Gunduz M., Nagatsuka H., Beder L. B., Cengiz B., ...Daha Fazla

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, cilt.134, sa.12, ss.1267-1276, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 134 Sayı: 12
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00432-008-0423-1
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1267-1276
  • Anahtar Kelimeler: Head and neck squamous cell carcinoma, Loss of heterozygosity, 14q, Microsatellite marker, Survival, D14S995, D14S67, TYROSINE-PHOSPHATASE D1, TUMOR-SUPPRESSOR GENE, ALLELIC LOSS, CANCER STATISTICS, DELETION, PROTEIN, REGULATOR, 13Q
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose and methods Loss of heterozygosity (LOH) in a chromosomal location indicates the presence of an inactivated tumor suppressor gene (TSG). Inactivation of TSG has a functional role in the tumorigenesis of head and neck squamous cell carcinoma (HNSCC). Based on the recent evidences of a putative TSG on chromosome 14, we examined LOH on chromosome 14q using eight polymorphic microsatellite markers in 50 cases of HNSCCs.