Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model

DAGISTAN Y., Karaca I., BOZKURT E. R., OZAR E., YAGMURLU K., Toklu A., ...More

ACTA CIRURGICA BRASILEIRA, vol.27, no.6, pp.383-387, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1590/s0102-86502012000600005
  • Journal Name: ACTA CIRURGICA BRASILEIRA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.383-387
  • Istanbul University Affiliated: Yes

Abstract

PURPOSE: Temozolomide (TMZ) has anti-tumor activity in patients with malignant glioma. Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are limited because of the hypoxic tumor microenvironment. We examined the combined effects of TMZ-HBO in a rat glioma model.