Production of the novel fibrous structure of poly(epsilon-caprolactone)/tri-calcium phosphate/hexagonal boron nitride composites for bone tissue engineering

Ozbek B., Erdogan B., EKREN N., OKTAR F. N., Akyol S., Ben-Nissan B., ...Daha Fazla

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, cilt.54, sa.2, ss.251-260, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s41779-017-0149-0
  • Dergi Adı: JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.251-260
  • Anahtar Kelimeler: Biopolymers, Biofibers, Biomaterials, Poly(epsilon-caprolactone), Composites, POLYCAPROLACTONE, SCAFFOLDS, FABRICATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Nanofibrous composites of the poly(epsilon-caprolactone) (PCL), tricalcium phosphate (TCP), and hexagonal boron nitride (h-BN) with different compositions were manufactured by using an economical and non-complicated method called electrospinning. Produced fibrous structures showed no bead formation and had a clean surface. Characterization of the composites showed that particles were successfully mixed with polymer phase. High cell activity of SaOS-2 cells on the composites was observed with SEM images. In addition, fibrous scaffolds are biocompatible with human bone tissue and are highly degradable.