DNA damage effects of inhalation anesthetics in human bronchoalveolar cells

ÇUKUROVA Z., Cetingok H., Ozturk S., Gedikbasi A., HERGÜNSEL O., Ozturk D., ...More

MEDICINE, vol.98, no.32, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 32
  • Publication Date: 2019
  • Doi Number: 10.1097/md.0000000000016518
  • Journal Name: MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: 8-hydroxy-2-deoxyguanosine, bronchoalveolar cells, comet assay, desflurane, DNA damage, inhalation anesthetics, sevoflurane, COMET ASSAY, IN-VIVO, HUMAN-LYMPHOCYTES, OXIDATIVE STRESS, DESFLURANE ANESTHESIA, SEVOFLURANE, GENOTOXICITY, ISOFLURANE, VITRO, HALOTHANE
  • Istanbul University Affiliated: Yes

Abstract

Background: The main objective was to evaluate and compare the local genotoxicity of sevoflurane and desflurane in bronchoalveolar cells, while the secondary outcome was to detect systemic oxidative DNA damage. To our knowledge, our study is the first one to evaluate the local effects of inhalation anesthetics in human bronchoalveolar cells in patients.