Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia

Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Saral N., Akgul C., Uysal M.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.146, sa.2, ss.160-164, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ejogrb.2009.06.007
  • Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.160-164
  • Anahtar Kelimeler: Preeclampsia, Polymorphism, DNA repair, APE1, XRCC1, XPD, BASE-EXCISION-REPAIR, SINGLE NUCLEOTIDE POLYMORPHISMS, ONSET ALZHEIMERS-DISEASE, BREAST-CANCER PATIENTS, FUNCTIONAL-CHARACTERIZATION, CELL CARCINOMA, DAMAGE REPAIR, LUNG-CANCER, ASSOCIATION, VARIANTS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Oxidative stress has been postulated as a major contributor to placental hypoperfusion and ischemia in pre-eclampsia (PE). Reactive oxygen species (ROS) generated during placental ischemia can cause oxidative damage to nucleic acids. Base excision repair (BER) and nucleotide excision repair (NER) are major pathways responsible for removing the oxidative DNA damage. Polymorphisms in DNA repair genes may be associated with differences in the repair efficiency of DNA damage.