Transcriptional repressor Blimp1 regulates follicular regulatory T-cell homeostasis and function

Yang G., Yang X., Zhang J., Li G., Zheng D., Peng A., ...Daha Fazla

IMMUNOLOGY, cilt.153, sa.1, ss.105-117, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 153 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1111/imm.12815
  • Dergi Adı: IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.105-117
  • Anahtar Kelimeler: autoinflammatory disease, neuroimmunology, neuroinflammation, regulatory T cells, T follicular helper cell, EXPERIMENTAL AUTOIMMUNE MYASTHENIA, GERMINAL CENTER REACTION, TREG CELLS, GRAVIS, ACTIVATION, EXPANSION, IMMUNITY, BALANCE, SUBSET, ROLES
  • İstanbul Üniversitesi Adresli: Evet

Özet

The B-lymphocyte-induced maturation protein 1 (Blimp1) regulates T-cell homeostasis and function. Loss of Blimp1 could double the proportion of follicular regulatory T (Tfr) cells. However, the effects that Blimp1 may have on the function of Tfr cells remain unknown. Here we document the function for Blimp1 in Tfr cells invitro and invivo. Data presented in this study demonstrate that Tfr cells indirectly inhibit the activation and differentiation of B cells by negatively regulating follicular helper T cells, so lowering the secretion of antibody. Lack of Blimp1 makes the immune suppression function of Tfr cells impaired invitro. In the invivo study, adoptive transfer of Tfr cells could reduce immune responses in germinal centres and relieve the muscle weakness symptoms of mice with experimental autoimmune myasthenia gravis. Blimp1 deficiency resulted in reduced suppressive ability of Tfr cells. This study identifies that Tfr cells are potent suppressors of immunity and are controlled by Blimp1.