Antibacterial and Antibiofilm Activities of Ceragenins against Pseudomonas aeruginosa Clinical Isolates

Bozkurt Guzel C., Hacioglu M., Inci G., SAVAGE P. B.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.16, no.4, pp.444-449, 2019 (ESCI) identifier identifier identifier


Objectives: Pseudomonas aeruginosa can cause life-threatening infections that are difficult to treat due to its high resistance to antibiotics and its ability to form antibiotic tolerant biofilms. Ceragenins, designed to mimic the activities of antimicrobial peptides, represent a promising new group of antibacterial agents that display potent anti-P. aeruginosa activity. The aim of this study was to evaluate the antibacterial and antibiofilm activities of ceragenins in comparison to colistin and ciprofloxacin against P. aeruginosa strains.